Nuevas moléculas en protección renal y cardiovascular en la DM y la ERC
La diabetes mellitus (DM) ha supuesto una creciente epidemia en las últimas décadas, dando veracidad a las predicciones del World Health Report en 1997 que estimaban un crecimiento progresivo de la enfermedad en los siguientes 20 años1. En 2012, la prevalencia de diabetes en EE.UU. era de un 14% (9% con diagnóstico conocido), pero como dato especialmente destacable y alarmante, existía un 38% de población en situación de prediabetes2.
De continuar esta tendencia, uno de cada 3 adultos en EE.UU. será diabético en 20503. El incremento de la prevalencia de DM se ha producido especialmente a expensas de la DM tipo 2 (DM-2), debido a cambios en el estilo de vida y aumento de la obesidad4. En EE.UU., el coste de la DM en 2012 ascendió a 245.000 millones de dólares, incluyendo la repercusión derivada de la falta de productividad del paciente con complicaciones. Afortunadamente, si bien entre 1990 y 2010 la población diabética en EE.UU. creció un 27%, el porcentaje de complicaciones ligadas a la DM descendió: amputaciones, del 22,6% al 18,8%; insuficiencia renal crónica terminal, del 13,7% al 6,1%; infarto de miocardio, del 3,8% al 1,8%; e ictus, del 3,1% al 1,5%5, probablemente por un mejor diagnóstico y cuidado tanto de la DM como de sus complicaciones.
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