Terapia Hormonal de la Menopausia (THM): 14 años después del Women’s Health Initiative Trial (Estudio WHI)
El cambio de estatus hormonal (descenso estrogénico) que caracteriza a la menopausia condiciona un cambio del perfil de salud respecto a la etapa premenopáusica. El descenso estrogénico condiciona la aparición de sintomatología típica (síntomas climatéricos, atrofia genitourinaria) y está implicado en una serie de cambios desfavorables en el perfil cardiovascular y en la masa ósea.
El impacto de los síntomas climatéricos en la calidad de vida de la mujer en su etapa post reproductiva fue el origen de la indicación del tratamiento hormonal sustitutivo a partir de la década de los 60 del siglo XX.
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